A lab-produced medication

What is Dimethylamylamine, and How Does it Work?

Dimethylamylamine is a lab-produced medication. A nasal decongestant, initially. Dimethylamylamine is being marketed as a dietary supplement for ADHD, weight reduction, athletic performance, and bodybuilding purposes.

It’s said that dimethylamylamine is naturally found in rose geranium oil. There are many names for this component. However, scientific testing indicates that this medication is not derived from plants. They may have introduced this medication chemically rather than receiving it naturally—dietary supplements or natural health products in Canada since it is a controlled substance.

Athletes often use Dimethylamylamine. Diamylamine was now on the World Anti-Doping Agency’s list of banned drugs in 2010. So avoid it, athletes.

They were discontinued from US military outlets due to safety concerns. New Zealand has likewise outlawed it. Many significant, life-threatening adverse effects have been reported.

How Does it Work?

Dimethylamylamine is hypothesized to be a stimulant like decongestants like pseudoephedrine and ephedrine. Some marketers claim it’s safer than ephedrine. But there is no scientific evidence to support this notion.

Effectiveness and Its Applications

There isn’t enough data to rate the efficacy for:

  • Attention deficit hyperactivity disorder
  • Loss of weight
  • Athletes’ Performance 
  • Bodybuilding
  • Other conditions.

To rank dimethylamylamine for these purposes, further evidence is required.

Is DMAA Safe to Consume?

The FDA has no evidence that consuming DMAA is safe. The FDA considers DMAA a dangerous food additive when added to dietary supplements. For this reason, the FDA advises consumers not to buy or use any DMAA-containing products. Blood vessel and artery narrowing cause high blood pressure, cardiovascular issues, including shortness of breath, arrhythmias, chest tightness, heart attacks, seizures, and other neurological and psychiatric diseases.

Side Effects

When used orally, dimethylamylamine is VERY RISKY! It is believed to act as a stimulant, increasing the risk of significant adverse effects, including fast pulse, high blood pressure, and heart attack or stroke.

This compound seems to raise heart rate and blood pressure in clinical studies, including dimethylamylamine.

Stroke, lactic acidosis, heart attack, and death have all been reported with dimethylamylamine.

Warnings and Precautions

Breastfeeding and Pregnancy

The usage of dimethylamylamine during pregnancy and breastfeeding is not well understood. To be on the safe side, avoid using it.

Hypertension (High Blood Pressure)

DMAA has stimulant properties and may raise blood pressure. Avoid using dimethylamylamine if you have high blood pressure.


Dimethylamylamine may act as a stimulant, constricting blood vessel walls. This may aggravate certain glaucomas. Dimethylamylamine is not recommended for glaucoma.

Arrhythmia (Irregular heartbeat)

Dimethylamylamine may act as a stimulant, causing a fast heart rate. This may aggravate heart arrhythmias.


Drunkenness and hypertension may be caused by dimethylamylamine. Dimethylamylamine should be stopped two weeks before a procedure.


DMAE should not be used by those who are taking certain drugs. The following medications are among them:

Inhibitors of acetylcholinesterase

Cholinesterase inhibitors are another name for these drugs. They’re mainly utilized to treat dementia in Alzheimer’s disease patients.

These medicines have an effect on the synthesis of Ach in the brain. DMAE may exacerbate cognitive deterioration. The following medications are included in this category:

  • Aricept
  • Cognex
  • Reminyl

Anticholinergic medications

Parkinson’s disease, COPD, and overactive bladder are among the disorders for which anticholinergics are used. They function by preventing Ach from acting on nerve cells.

People who require these medicines shouldn’t use DMAE since it may worsen the effects of Ach.

Cholinergic medications

Cholinergic medications may either prevent, enhance, or imitate Ach’s effects. They’re used to treat various ailments, such as Alzheimer’s and glaucoma. These drugs may be rendered ineffective if DMAE is present.


If you use some blood-thinning drugs, such as Warfarin, you shouldn’t take DMAE.


The correct dosage of dimethylamylamine is determined by several variables, including the recipient’s age, health, and other circumstances. There is insufficient scientific evidence to define a suitable dosing range for dimethylamylamine. Remember that natural products aren’t always safe, and doses are crucial. Before using, be sure to read the product label and contact your pharmacist, physician, or other healthcare experts.

Potential Benefits

Wrinkles will be reduced, and drooping skin will be firmed. When used for 16 weeks, a face gel containing 3 percent DMAE was shown to effectively minimize fine lines around the eyes and on the forehead, according to randomized clinical research published in the American Journal of Clinical Dermatology. 

According to the study, it also enhanced lip shape and fullness and the overall look of aged skin. According to research conducted on people and mice, DMAE may moisturize skin and improve its look.

Assist memory. Although there is some anecdotal evidence that DMAE may help with memory loss in Alzheimer’s disease and dementia, there are no studies to back this up.

Improve your athletic performance. When combined with other vitamins and supplements, anecdotal data suggests that DMAE may increase athletic abilities. However, further research is required to back this conclusion.

Reduce your level of hyperactivity. DMAE was reported to aid decrease hyperactivity, calm children, and help them concentrate in school in studies conducted on children in the 1950s, 1960s, and 1970s. There have been no current investigations to confirm or refute these conclusions.

Encourage a more positive outlook. Some individuals feel that DMAE might assist in improving mood and depression. In a short trial on patients with aging-related cognitive loss conducted in 1977, DMAE improved sadness, anxiety, and irritability. It was also shown that DMAE helped to boost motivation and initiative.

DMAA Pre Workout

You’ll notice a significant improvement in overall performance when you utilize a DMAA Pre-workout.

Which sounds fantastic, doesn’t it?

However, there are a few things you should know about this substance.

Bodybuilders and fitness fanatics were big fans of this sort of supplement.

It may significantly improve energy and physical performance due to its significant potency.

Many supplements included the chemical 1,3 Dimethylamylamine, promoted as a performance enhancer and energy booster.

It may also be very harmful and have serious consequences. The FDA declared all DMAA-containing pre-workouts or other supplements unlawful in 2013.

On the other hand, Wrecked is a product with very comparable effects that we’ll discuss shortly.

Pre-Workouts Effects Of DMAA

After around 20 to 30 minutes after taking a scoop of DMAA before exercise, you’d see the results.

You can probably determine what occurs next since 1,3-dimethylamylamine is an amphetamine derivative.

That’s right, and there’s a massive burst of energy.

It’ll be unlike anything you’ve ever known. Because of the boost, you could raise the weights on each workout.

In conclusion:

  • A boost in energy levels.
  • More focus 
  • More power and strength.
  • Pumps that are insane.

The only drawback was that you would suffer a crash when it wore off.

And if you take too much, you may have unpleasant side effects. Only a few pre-workouts, such as Wrecked, come close to replicating the benefits of the original.

What is FDA doing to remove dietary supplements containing DMAA off the market?

The FDA has utilized several strategies to remove DMAA-containing goods from the market. Actions made to safeguard customers and pull goods off the shelf swiftly.

Since 2012, the FDA has advised firms that selling DMAA-containing goods is illegal. When we uncover DMAA-containing items during facility inspections, we notify companies and provide them the chance to recall and destroy them. Most DMAA-containing products are no longer distributed.

When companies refuse to cooperate freely, the FDA takes further steps. After USPLabs first failed to comply, the FDA administratively detained two DMAA-containing products, OxyElite Pro and Jack3d, in 2013. USPLabs decided to halt production using DMAA and destroyed the detained items, believed to be worth over $8 million.

In 2013, the FDA confiscated DMAA-containing goods from Hi-Tech Pharmaceuticals; in April 2017, a federal district judge decided the items were adulterated and ordered their destruction.

It found that DMAA is not a dietary element and is not widely regarded as safe, and condemned and forfeited the confiscated items containing DMAA. Hi-Tech Pharmaceuticals asked the Supreme Court to reconsider the matter in 2020. It was disposed of on November 12, 2020.

When it finds DMAA products, the FDA removes them from the market. No one should purchase or use anything containing DMAA.

How can customers tell whether a product labeled as a dietary supplement contains DMAA?

On the product label, consumers should search for DMAA. It might also be written as:

  • Dimethylamylamine
  • Methylhexanenamine
  • Geranamine
  • Methylhexanamine
  • 1,3-DMAA
  • 1,3-Dimethylpentylamine
  • 1,3-Dimethylamylamine
  • 2-Hexanamine, 4-methyl- (9CI)
  • 2-Amino-4-methylhexane
  • 4-Methyl-2-hexylamine
  • 4-Methyl-2-hexanamine

Pelargonium graveolens extract or Geranium extract may also be included on certain items, indicating that they contain DMAA.

What should customers do if they feel DMAA-containing dietary supplements have caused harm?

Those who fear being damaged by DMAA-containing products should notify their doctor. On the other hand, consumers may report such instances directly to FDA through the Safety Reporting Portal. Consumers may also contact the firm whose name and contact information are on the product label.

Is DMAA a Steroid?

1,3-dimethylamylamine, or DMAA for short, is the prohibited chemical in this supplement. When combined with coffee, it’s a stimulant that reportedly transforms you into an exercise machine capable of running through walls.

It looks like ephedra (which is now outlawed and has been linked to the deaths of some individuals, including former Orioles pitcher Steve Bechler). For taking it, a slew of Rays prospects was banned. 

The US Military has outlawed DMAA after two soldiers died after taking it during basic training. It seems to be serious business. It also contains pregnenolone, a steroid hormone prohibited by the Olympics, so I assumed that would offer me insight into what it would be like to use an illegal steroid.

So I went out and purchased a bottle. And I went to my doctor and told him about any possible side effects or concerns, and despite his worry, he gave me the green light as long as I was cautious and had frequent checks to keep my heart from exploding.

To summarize his findings, Mr. Tworischuk, our willing lab rat, learns that this chemical causes not just faster recovery times, more stamina, and more significant gains but also an unusual enthusiasm for, you know, working out. 

According to the author, using this (or anything else) won’t give someone who doesn’t have baseball abilities baseball skills, but it may help them become in better shape. It’s just one piece of information, but it’s fascinating.

I guess that PED usage helps, maybe significantly, but I also believe that we’ll never be able to tell – let alone measure – how much it helps. On another level, I’m not convinced that the World Anti-Doping Association, for example, draws a clear border between permissible and prohibited chemicals. There’s some science behind such judgments, but there’s also a lot of frenzies and public-relations motivations.

More to the point, does the man using legal supplements like creatine, whey, BCAA supplements, and Red Bull come at his results more cleanly and honestly (whatever those terms imply in this context) than the guy taking, say, HGH (whose athletic advantages are very dubious)? Is he getting less benefit from his procedures than the man who uses the Officially Unacceptable stuff? I have no idea, and I assume that many of those entrusted with establishing such distinctions have no notion either.

Nobody loves a gray area, but that’s exactly what this is to me: less subtlety in some regions, more nuance in others, but phenomena fraught with ambiguity. “I don’t know,” we don’t speak enough about this and so many other controversial topics.

How do DMAE and DMAA differ?

These two substances are not the same. DMAE, also known as dimethylaminoethanol, is a precursor to acetylcholine’s neurotransmitter and a brain health and mood support component. This component is considered safe and is often found in dietary supplements.

The stimulant 1,3-dimethylamylamine (DMAA) is a dietary supplement that is widely found in sports nutrition products. Because it has been linked to heart failure and strokes, DMAA is now being phased out of most supplement formulations. There are currently no Beachbody products that include DMAA in their formulations.

Final Thoughts

The advantages of consuming DMAE haven’t been shown in a scientific study. Skin, hyperactivity, mood, cognitive abilities, and memory may all improve with DMAE. However, before taking DMAE, discuss any other drugs you’re taking with your doctor.

If you’re pregnant or may become pregnant, avoid using DMAE to prevent a particular form of birth problem.

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